The pregnancy category for a single 150 mg dose of fluconazole for vaginal candidiasis is category C based on data from animal studies that showed an adverse effect on the fetus. There are no adequate and well-controlled studies of fluconazole in pregnant women.
What happens if you take fluconazole while pregnant?
Any maternal exposure to fluconazole during pregnancy — whether in low or high doses — may increase the risk for spontaneous abortion, and high-dose fluconazole during the first trimester may increase the risk for cardiac septal closure anomalies, researchers reported recently in the Canadian Medical Association …
Can fluconazole cause a miscarriage?
Specifically, women who took a lower dose of fluconazole (under 150 milligrams) had more than a doubling of their odds for miscarriage, compared to women who hadn’t taken the drug while pregnant. The increase in risk more than tripled for women who had taken fluconazole at a higher dose, Berard’s team found.
Can you take yeast infection pill while pregnant?
Oral medication isn’t recommended if you’re pregnant. Some commonly prescribed antifungals — such as fluconazole (Diflucan) — should be avoided, especially during the first trimester.
Which antifungal is safe in pregnancy?
Careful consideration of the benefit to the mother and the risk to the fetus is required when prescribing antifungal therapy in pregnancy. Imidazoles are considered safe as topical therapy for fungal skin infections during pregnancy. Nystatin is minimally absorbed and is effective for vaginal therapy.
Which oral antifungal is safe in pregnancy?
Among the antifungal medications, it is possible that terbinafine is the safest one currently available for use in pregnancy, particularly of the oral formulations.”
Does fluconazole affect early pregnancy?
In summary, it is unlikely that the use of a single low dose of fluconazole during early pregnancy would greatly increase the chance of birth defects. However, the use of high dose fluconazole for many weeks might be associated with a small increase of birth defects.
How safe is fluconazole?
A prescription-event monitoring (PEM) study has confirmed that fluconazole, a bis-triazole oral antifungal drug, is a safe and effective treatment for vaginal candidiasis.
Can yeast infection pills cause miscarriage?
(Reuters Health) – Pregnant women who take fluconazole, an oral antifungal used to treat vaginal yeast infections, may be more likely to have miscarriages than women who don’t take this pill during pregnancy, a Canadian study suggests.
How quickly does fluconazole work?
If you have vaginal thrush, balanitis or oral thrush, your symptoms should be better within 7 days of taking fluconazole. If you have a serious fungal infection, ask your doctor how long it will take for fluconazole to start to work. It may be 1 to 2 weeks before it reaches its full effect.
What are the side effects of fluconazole?
Nausea, vomiting, diarrhea, stomach upset/pain, headache, dizziness, or hair loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Is clotrimazole safe in pregnancy?
Pregnancy and breastfeeding
Clotrimazole pessaries and internal and external cream are generally considered safe to use during pregnancy.