While there is a consensus that ACE inhibitor/ARBs should be discontinued when pregnancy is diagnosed to prevent fetal renal damage and associated complications, women often do not plan pregnancy, and fetal exposure in the first trimester is inevitable.
Can you take ARBs while pregnant?
Drugs that affect the renin-angiotensin system, such as angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors are not typically recommended for pregnant women because of their potential fetal toxicity.
Is valsartan contraindicated in pregnancy?
Do not take valsartan if you are pregnant. If you become pregnant while you are taking valsartan, stop taking valsartan and call your doctor immediately. Valsartan may cause death or serious injury to the fetus when taken in the last 6 months of pregnancy.
What pregnancy category are ARBs?
Currently, ACE inhibitors and ARBs are rated pregnancy category C during the first trimester and D during the second and third trimesters. data has indicated that use of ACEIs and ARBs during the first trimester may result in increased risk of fetal abnormatlities.
Are ARBs recommended in gestational hypertension?
They recommend that for women with mild gestational hypertension or preeclampsia (SBP < 160mmHg or DBP < 110 mmHg), antihypertensives are not recommended (the quality of this evidence is moderate and the strength of this recommendation is qualified).
Why are ACEI and ARBs contraindicated in pregnancy?
It is well accepted that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during the second and third trimesters of pregnancy because of increased risk of fetal renal damage. First-trimester use, however, has not been linked to adverse fetal outcomes.
Can I take a beta blocker while pregnant?
β-Blockers are the most commonly used class of medication for treating cardiac conditions in pregnant women. Despite the common use of this class of medication, data that support its safety are limited. β-Blockers cross the placenta and potentially can cause physiological changes in the fetus.
Is valsartan safe now 2020?
Today, the U.S. Food and Drug Administration approved a new generic of Diovan (valsartan). Valsartan is an angiotensin II receptor blocker (ARB) that treats high blood pressure and heart failure.
Is weight gain a side effect of valsartan?
Weight gain is not listed on the valsartan label as a side effect. But a study of FDA reports found incidents of weight gain among patients who took the drug.
Who should not take ARBs?
Although doctors often prescribe ARBs to help protect the kidneys, people with certain kidney conditions — like narrowing of the arteries feeding the kidneys (renal artery stenosis) or very poor kidney function — shouldn’t take ARBs.
What does pregnancy category C mean?
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Why is lisinopril bad for pregnancy?
When lisinopril, or any ACE inhibitor, is taken during the second or third trimesters of pregnancy, it can cause low levels of amniotic fluid (the fluid that surrounds the baby). Low levels of amniotic fluid can lead to health problems for the developing baby.