Why is amlodipine contraindicated in pregnancy?

Animal studies have shown significantly decreased litter size, increased intrauterine deaths and prolongation of gestation and duration of labor when this drug was given before mating, throughout mating, and during gestation.

Is amlodipine safe in pregnancy?

Amlodipine and Pregnancy

Amlodipine falls into category C. There are no good studies in pregnant women. Amlodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if amlodipine will harm your unborn baby.

Does amlodipine cause birth defects?

The incidence of morphologic abnormalities in the offspring of hypertensive mothers treated with amlodipine in early pregnancy was not higher than in mothers treated with or without other antihypertensives.

Why are calcium channel blockers contraindicated in pregnancy?

Calcium channel blocker use in the third trimester was associated with increased risk of neonatal seizures, jaundice, and hematologic disorders (relative risk [RR] 3.6, 95% CI 1.3 to 10.4).

Why are the common antihypertensive drugs contraindicated in pregnancy?

Angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blocking agents are contraindicated in the second or third trimesters because of toxicity associated with reduced perfusion of the fetal kidneys; use is associated with a fetopathy similar to that observed in Potter’s syndrome (ie, bilateral …

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What is the safest blood pressure medication during pregnancy?

Methyldopa has been used for decades to treat high blood pressure in pregnancy and it appears to be safe. Labetalol has been extensively studied and has become increasing prescribed in pregnancy. Labetalol is now commonly used as a first-line treatment choice.

Why is amlodipine banned in Canada?

The affected medication may contain traces of N-nitrosodimethylamine (NDMA), a “probable human carcinogen” that could increase the risk of cancer through long-term exposure above acceptable levels, Health Canada says.

How do I stop taking amlodipine?

Do not stop taking amlodipine suddenly. Although no “rebound” effect has been reported, it is better to slowly decrease the dosage over a period of time. Your doctor may advise you to take sublingual nitroglycerin for any break-through angina pain.

What are the contraindications of amlodipine?

Who should not take AMLODIPINE BESYLATE?

  • severe narrowing of the aortic heart valve.
  • significantly low blood pressure.
  • severe liver disease.

Which antihypertensive is not safe in pregnancy?

ACE-Is and angiotensin receptor blockers should be avoided in all trimesters; when administered in the second and third trimesters, they are associated with a characteristic fetopathy, neonatal renal failure, and death, and, thus, are contraindicated.

Why diuretics are contraindicated in pregnancy?

Diuretics given after the first trimester interfere with normal plasma volume expansion, which may exacerbate the volume depletion in pre-eclampsia and cause intrauterine growth retardation [3]. Diuretics have not been reported to have teratogenic effects.

Which calcium channel blockers are safe in pregnancy?

They include amlodipine, diltiazem, felodipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine, and verapamil. In the UK, the National Institute for Health and Care Excellence (NICE) recommends nifedipine as one of the medicines for treating high blood pressure during pregnancy.

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